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Otmakhova and Lisman, 1996

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Oral supplements were convenient but useless

There is no official medical or FDA definition of "microdosing" for GLP-1 drugs

mansoni, which was assigned to the action of a metabolite (having the general structure 5, Figure 9) rather than to OPZ itself [58]

The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients